Nearly one in every seven couples are infertile, which indicates they haven't been able to conceive naturally despite having frequent, unprotected sexual intercourse for a year or more. Even though the research focus of infertility and its treatment has historically been on women, infertility affects both men and women equally, with male-factor causes contributing to infertility approximately one-half of the time. As per cultural assumption, men are virile and can quickly become fathers; however, the incidence of male sexual problems is continuously growing at an alarming rate.
Furthermore, it is difficult to obtain accurate values for the true prevalence of male sexual dysfunctions. Many patients do not seek medical attention, and many physicians hesitate to ask patients about their sexual health. It is estimated that over 150 million men worldwide suffer from sexual dysfunction. Due to reporting bias, cultural factors, a general failure by many physicians to inquire about their male patients' sexual health, and embarrassment issues, these values are likely a gross underestimation of the actual number of men with sexual problems.
The pathophysiology of the male reproductive disorder is complex as multiple systems contribute to delivering reproductive functions. Besides structural deformities, male reproductive disorders are mainly erectile dysfunction, low libido, poor sperm and semen quality. A plethora of evidence suggests that in reproductive dysfunctions, there is a close interplay between the psychological and physiological status of the body. With the rising prevalence of psychological disorders viz stresses, anxiety, and depression, males' number of reproductive disorders is also increasing. In stressed out males, the outcomes are worse, as an imbalance in brain function may impose a harmful impact on the physiology of the reproductive systems and vice versa. One of the hypotheses of this fact can be that psychological disorders negatively influence the physiology of the hypothalamic-pituitary-adrenal axis, or HPA axis, which ultimately affects reproductive functions. Similarly, male suffering from sexual dysfunctions has higher chances to develop stress, anxiety, and depression.
Despite the continuous advancement in the management or treatment of reproductive disorders, the number is not decreasing. Considering the tolerability and safety concern along with the
targeted effects of modern medicines, natural medicines can also be given due consideration. As per Ayurveda, classical or natural medicine is safe, tolerable, and effective as it acts on multiple underlying pathophysiological pathways. These multifactorial actions from natural treatment can be rationalized for an effective, safe, and tolerable approach to treating complex ailments like males' reproductive disorders. Several phytoconstituents found in the botanicals listed below are beneficial in maintaining and managing male reproductive health. Some of them are:
Kaunch seeds (Mucuna pruiens): The seeds are a rich source of L-DOPA that increases the dopamine level in the brain. It increases the plasma testosterone level and induces the activation of sexual behavior. It also improves semen quality by restoring antioxidant levels and reducing lipid peroxide content.
Gokhru (Tribulus terrestris): The fruit increases nitric oxide production, which enhances the smooth muscles relaxation that results in increased blood flow in the columns of spongy tissue within the shaft of the penis (the corpora cavernosa and corpus spongiosum) and thus manages erectile dysfunction.
Ashwagandha (Withania somnifera): Indian ginseng produces GABA-like activity that decreases neuron activity and inhibits nerve cells from over-firing. The standardized extract of Ashwagandha was proved effective on the adverse effects of stress. It increases energy, reduces fatigue, better sleep, enhances the sense of well-being, and reduction of cortisol levels up to 26%. Thus, it improves Psycho Sexual endurance.
Jaiphal (Myristica fragrans): By facilitating the activity of norepinephrine, a neurotransmitter, in the central nervous system improves sexual function by its chemical constituents such as sterols, phenols, alkaloids, and amino acids.
Pumpkin seeds: Pumpkin seeds are the rich source of Zinc that exerts the antioxidant effect and improves fertility and male sexual health, strengthening prostate gland and male hormonal function. Thus, improving sperm morphology and motility.
Vidarikhand (Pueraria tuberosa): Pueraria tuberosa possesses numerous activities like nootropic, antioxidant, and antifertility. It increases sperm count by improving the androgenic and sexual behavior parameters.
By acting multidimensionally, these herbal phytoconstituents act on the crosstalk between psychological and physiological pathways and alleviate the male reproductive disorders' root cause. Recognizing the increasing burden of male reproductive issues, Aimil Pharmaceuticals (I) Ltd has developed a unique polyherbal formulation (Semento capsules) to improve male reproductive health. This polyherbal formulation contains biologically active herbal phytoconstituents from the best quality of herbs reported to treat erectile dysfunction, low libido, poor sperm, and semen quality for better male fertility.