Dengue fever is one of the most prevalent and fast-spreading mosquito-borne infection worldwide. As per the reports, dengue virus infects an estimated 390 million people and causes 25000 deaths yearly. It is also stated by WHO that its explosive outbreak in tropical & sub-tropical regions is strongly influenced by rainfall and temperature, risking dengue fever infection in about 2/5th of the entire world’s population in more than 100 countries.
Looking at the alarming numbers & the spectrum of illnesses of this infectious disease ranging from Mild Febrile Fever to Dengue Hemorrhagic Fever (DHF) or Dengue Shock Syndrome (DSS), the infection continues to threaten the population. Talking more on its clinical manifestation in patients, the disease alongside fever is majorly associated with a common condition: Thrombocytopenia (low or subsequently decreasing platelet count) is almost present in all mild or severe cases of dengue. The count tends to drop below the average level (150,000–450,000 platelets/μL) and may reach up to <40000 platelets/μL during 3–7 days of fever in many patients, making this infection a life-risking disease.
The development of thrombocytopenia mainly rests on two events: Decreased production of platelet in the bone marrow and increased destruction or clearance of platelet from peripheral blood. With no specific medication available for dengue infection, symptomatic treatment, fluid retention is the only line of treatment followed by various systems of medicine. Considering the above treatment protocol, Ayurveda believes that symptomatic treatment for sustaining platelet, blood profile and improving immunity in an infected person in the early stage is a critical way to prevent this condition from worsening.
Various studies have shown the countless benefits of Phyto-constituent obtained from herbal extracts that can help in resolving such conditions; some of them are-
Papita (Carica papaya) - Recently, there has been heated discussion on the efficacy of papaya leaves in treating dengue, especially in Hemorrhagic Dengue Fever with low platelet count. In various reports, it has been found that papaya leaves contain various bio-active constituents like saponins, tannins, glycosides & many more that act on platelet formation. In addition, many studies with papaya leaves also demonstrated the significant inhibition of hemolysis by stabilizing the cell membrane & revealing an increase in thrombocyte or platelet count in patients with dengue.
Ashwagandha (Withania somnifera) - Ashwagandha, also known as the Indian winter cherry, has been reported to increase the hemoglobin, total red blood cells & white blood cells in immune suppressed conditions. In addition, it tends to increase bone marrow cellularity & can enhance stem cell proliferation, resulting in increased blood cell count & better immunity.
Guduchi (Tinospora cordifolia) - A well-known rejuvenating herb reported to activate macrophages, the first line of defense in our body, and shown to play a crucial role in improving innate (non-specific) and adaptive (specific) immunity in infections like dengue, where immunity is severely compromised. Also, alongside improving white blood cell count (WBC), it is found to increase serum Ig concentrations, hence overall helps in speedy & healthy recovery.
Following the belief of ancient science, AIMIL Pharmaceutical brings a new ray of hope to the medical fraternity by developing a scientifically backed herbo-mineral formula AMYRON, essentially made with more than 40 nutritional herbs & including Papaya leaves, Ashwagandha, and Guduchi, that synergistically work in improving declined platelet count corrects deranged blood profile & boosts patient’s immunity. Besides these benefits, Amyron provides complete nutrition to the patient suffering from dengue by supplementing minerals, vitamins, essential fatty acids like omega-3 & omega-6, and antioxidants that collaboratively offer fast, sustainable, and speedy recovery of the sufferer.